Muscadine 玛斯克汀葡萄

产品特性 

1.优越的抗氧化剂

• 玛斯克汀葡萄是最稀有、最强效的抗氧化水果

• 玛斯克汀葡萄拥有独特的多酚特性，可提供多种健康益处

• 玛斯克汀葡萄含有大量白藜芦醇，鞣花酸，低聚原花青素（OPC），和大量类黄酮（槲皮黄酮和儿茶酚）

• 玛斯克汀葡萄含有所有石榴，浆果类，绿茶和红酒所含有的的抗氧化剂

2.比白藜芦醇更高的生物活性

• 玛斯克汀与白藜芦醇抗癌活性对比(Hudson et al 2007)
  

• 通过抑制AMPK p38, ERK1/ERK2 and PI3K/Akt 的生产途径，玛斯克汀可诱发前列腺癌细胞死亡，而白藜芦醇并没有影响癌细胞。

• 玛斯克汀杀死前列腺癌细胞的活动归因于非白藜芦醇多酚

• 对正常癌细胞生长没有影响

• 作者（实验员）得出结论，“玛斯克汀可能成为有效的化学预防物

玛斯克汀含有更多纤维、矿物与维他命，更低含量的糖分和碳水化合物。   (ref:USDA *45300522, RED SEEDLESS GRAPES)

玛斯克汀含有更高含量的活性酚类物质，包括白藜芦醇，儿茶酚， OPC以及其他单宁酸

作用机制 

来自玛斯克汀的多酚抗氧化剂抑制活性氧（ROS）和炎症，对新陈代谢、线粒体生物发生产生保护作用，以支持健康衰老、心血管和大脑健康，以及健康的体重和血糖。

产品优势 

• 玛斯克汀是唯一比白藜芦醇更强效的抗氧化剂

• 玛斯克汀是唯一提供大量主要多酚的水果

• 玛斯克汀是唯一集合了葡萄、石榴和绿茶所含的抗氧化剂的水果

• 玛斯克汀是唯一北美南部自然环境下生长的葡萄

• 玛斯克汀是唯一完整起源于农场的美国葡萄

应用市场 

功能性食物

膳食补充剂

超级水果

即饮饮料                 

饮料粉

药片与胶囊

个人护理：化妆品&皮肤护理

天然抗氧化剂

天然食用色素

参考文献 

Collard M, et al. Muscadine Grape Extract Reduces Lung and Liver Metastasis in Mice with Triple Negative Breast Cancer in Association with Changes in the Gut Microbiome. Curr Dev Nutr. 2019;3(Suppl 1):P05-017-19.

Duncan AV, et al. Beneficial Cardiovascular Effects of Muscadine Grape Extract in Normotensive Female Rats. FASEB J. 2016;30(Suppl 1):1175. 

Duncan AV, et al. Muscadine Grape Extract Improves Exercise Capacity and Reduces Oxidative Stress in Aging Transgenic (mRen2)27 Hypertensive Female Rats. FASEB J. 2017;31(Suppl 1):793.12.

Banini AE et al. Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Nutrition. 2006 Nov-Dec;22(11-12):1137-45.

Brown JC et al. Activities of muscadine grape skin and quercetin against Helicobacter pylori infection in mice. J ApplMicrobiol. 2011 Jan;110(1):139-46.

Brown JC et al. Antibacterial effects of grape extracts on Helicobacter pylori. Appl Environ Microbiol. 2009 Feb;75(3):848-52.

Burton LJ et al. Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis. 2015 Sep;36(9):1019-27.

Burton LJ et al. Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells. BMC Complement Altern Med. 2014 Mar 12;14:97. 

Farrar JL et al. Inhibition of protein glycation by skins and seeds of
the muscadine grape.Biofactors. 2007;30(3):193-200. 

God JM et al. Anticancer effects of four varieties of muscadine grape. J Med Food. 2007 Mar;10(1):54-9.

Gourineni V, Shay NF, Chung S, Sandhu AK, Gu L. Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice. J Agric Food Chem. 2012 Aug 8;60(31):7674-81. 

Hudson et al. Inhibition of Prostate Cancer Growth by Muscadine Grape Skin Extract and Resveratrol through Distinct Mechanisms. Cancer Res 2007;67(17):8396–405

Hudson TS et al. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Res. 2007 Sep 1;67(17):8396-405.

Kim TJ et al. Antibacterial activity of fresh and processed red muscadine juice and the role of their polar compounds on Escherichia coli O157:H7. J ApplMicrobiol. 2009 Aug;107(2):533-9.

Kim TJ et al. Antimicrobial effect of water-soluble muscadine seed extracts on Escherichia coli O157:H7. J Food Prot. 2008 Jul;71(7):1465-8.

Kim TJ et al. Inactivation of Enterobactersakazakii by water-soluble muscadine seed extracts. Int J Food Microbiol. 2009 Feb 28;129(3):295-9.

Lutterodt H et al.  Fatty acid composition, oxidative stability, antioxidant and antiproliferative properties of selected cold-pressed grape seed oils and flours. Food Chem. 2011 Sep 15;128(2):391-9. 

McDougald LR et al. Enhancement of resistance to coccidiosis and necrotic enteritis in broiler chickens by dietary muscadinepomace. Avian Dis. 2008 Dec;52(4):646- 51.

Mellen PB et al. Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. J Am CollNutr. 2010 Oct;29(5):469-75.

Mertens-Talcott SU et al. Extracts from red muscadine and cabernet sauvignon wines induce cell death in MOLT-4 human leukemia cells. Food Chem. 2008 Jun 1;108(3):824-32.

Mertens-Talcott SU et al. Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitisrotundifolia). J Agric Food Chem. 2006 Jul 26;54(15):5336-43. 

Noratto GD et al. Polyphenolics from açaí( Euterpe oleracea Mart.) and red muscadine grape (Vitisrotundifolia ) protect human umbilical vascular Endothelial cells (HUVEC) from glucose- and lipopolysaccharide (LPS)-induced inflammation and target microRNA-126. J Agric Food Chem. 2011 Jul 27;59(14):7999-8012.

Paller CJ et al. A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination. Prostate. 2015 Oct;75(14):1518-25. 

Sandhu AK and Gu L. Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitisrotundifolia (Muscadine Grapes) As determined by HPLC-DAD-ESI-MS(n). J Agric Food Chem. 2010 Apr 28;58(8):4681-92.

Shi J et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food. 2003 Winter;6(4):291-9.

Talcott ST and Lee JH.Ellagic acid and flavonoid antioxidant content of muscadine wine and juice. J Agric Food Chem. 2002 May 22;50(11):3186-92.

Weiguang Y et al. Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Research International 2006 39(5).

Xu C et al. Antioxidant, antibacterial, and antibiofilm properties of polyphenols from muscadine grape (VitisrotundifoliaMichx.) pomace against selected foodborne pathogens. J Agric Food Chem. 2014 Jul 16;62(28):6640-9. 

Xu C et al. Application of muscadine grape (VitisrotundifoliaMichx.) pomace extract to reduce carcinogenic acrylamide. Food Chem. 2015 Sep 1;182:200-8.

Yilmaz Y and Toledo RT. Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem. 2004 Jan 28;52(2):255-60.

You Q et al. High-performance liquid chromatography-mass spectrometry and evaporative light-scattering detector to compare phenolic profiles of muscadine grapes. J Chromatogr A. 2012 Jun 1;1240:96-103.

You Q et al. Inhibitory effects of muscadineanthocyanins on α-glucosidase and pancreatic lipase activities. J Agric Food Chem. 2011 Sep 14;59(17):9506-11. 

Zhao L et al. Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation. Food Funct. 2015 Jul;6(7):2293-302.

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